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nitrofurantoin is highly stable to the development of bacterial resistance, a property thought to be due to its multiplicity of mechanisms of action.

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this is clearly not the case for any strain, indicating that both susceptible and resistant bacteria would be unable to establish and sustain an infection at therapeutic concentrations of nitrofurantoin.

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the singular indication for nitrofurantoin is the treat- in vitro antagonism between nitrofurantoin and the ment and long-term prophylaxis of lower utis caused quinolones has been shown, but a demonstration of by susceptible bacteria; it is not used as a bacterial sup- clinical relevance warrants further study.

However, a retrospective chart review may suggest nitrofurantoin is not contraindicated in this population.

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